In situ complement activation in porcine membranoproliferative glomerulonephritis type II
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Classical complement pathway activation in membranoproliferative glomerulonephritis.
Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...
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Membranoproliferative glomerulonephritis (MPGN) is characterized by proliferation of mesangial and endothelial cells and by thickening of the peripheral capillary walls. Type II of the MPGN is associated with complement abnormalities which are factor H deficiencies due to mutations in the complement factor H (CFH) gene. We report a 15-year-old boy diagnosed with MPGN II in whom genetic analyses...
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We have recently described hereditary membranoproliferative glomerulonephritis type II in the pig. All affected animals had excessive complement activation, revealed as low plasma C3, elevated plasma terminal complement complex, and massive deposits of complement in the renal glomeruli, and eventually died of renal failure within 11 wk of birth. The aim of the present study was to investigate t...
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1. Van Den Berg TJ. On the relation between glare and straylight. Doc Ophthalmol. 1991;78(3-4):177-181. 2. Van Den Berg TJ, Van Rijn LJ, Michael R, et al. Straylight effects with aging and lens extraction. Am J Ophthalmol. 2007;144(3):358-363. 3. Cerviño A, Hosking SL, Montés-Micó R, Alió JL. Retinal straylight in patients with monofocal and multifocal intraocular lenses. J Cataract Refract Sur...
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Membranoproliferative glomerulonephritis type II (MPGN II) is a rare disease characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidney and often within Bruch's membrane in the eye. The diagnosis is made in most patients between the ages of 5 and 15 yr, and within 10 yr, approximately half progress to end-stage renal disease, occasi...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.00765.x